The byway provides access to many sites in and near the Brandywine Valley in Delaware County including Ridley Creek State Park, Media Theatre, the Brandywine River Museum, Tyler Arboretum, and the Pennsylvania Veterans Museum.
The byway runs through rural areas of farmland along the west bank of the Delaware River.
The byway is located near the historic Lincoln Highway and is near points of interest including the QVC Studio Tour, the American Helicopter Museum, and Fox Leap Vineyards.
[9] The Gateway to the Endless Mountains Scenic Byway runs along US 6 in Tunkhannock, Wyoming County.
The byway is in the Endless Mountains region and provides access to various sites including the Dietrich Theater in Tunkhannock and the Bird Song Winery in Dushore, Sullivan County.
[10] The Governor Casey Scenic Byway runs along the US 6 freeway in Lackawanna County between I-81 in Dunmore and PA 247 in Jessup.
[11] The Grand View Scenic Byway runs along Grandview Avenue, McArdle Roadway, and Sycamore Street in Pittsburgh, Allegheny County.
Nearby the byway is Bradford, which is home to Crook Farm Homestead and the Zippo/Case Visitors Center.
The byway runs through the Pennsylvania Dutch Country, serving the Middlecreek Wildlife Preserve, the Lebanon Valley Rail Trail, and the Cornwall Iron Furnace.
The byway provides access to many sites along Lake Erie, including Presque Isle State Park, the Erie Maritime Museum, the Presque Isle Lighthouse, the 1867 Land Lighthouse, Mazza Vineyards, the Tom Ridge Environmental Center, and the USS Niagara.