This is a list of issue covers of TV Guide magazine from the decade of the 2000s, from January 2000 to December 2009.
The entries on this table include each cover's subjects and their artists (photographer or illustrator).
From the beginning of this decade until the 4/3/2004 cover, dates indicated fell on a Saturday (the TV listings were in a Saturday-to-Friday pattern).
Issue dates from 10/17/2005 onward fall on a Monday (Monday-to-Sunday listings).
NOTE: Beginning in 2006, TV Guide occasionally produced 2-week "double issues."