Through a series of flashbacks, he tells the viewers how he was formerly a homeless vagrant who had undergone a doctor's experiment in order to transfer a cat's gland into his brain, giving him its nine lives and the ability to temporarily resurrect a number of times.
In 1950, gold-digging secretary Cathy Finch (Demi Moore) marries Charlie Marno (Jeffrey Tambor), an overweight, unhygienic, and grotesque slob of a man after being told by a fortune teller, Madame Vorna (Natalia Nogulich), that he will die shortly after inheriting a large sum of money.
After being rejected for his age and realizing plastic surgery cannot do much, Carlton ends up meeting a discredited doctor who helps him slowly switch bodies with Hans (Rick Rossovich), an East German refugee.
Reno Crevice and Sam Forney (Lance Henriksen and Kevin Tighe), a pair of rival gamblers who hate each other with a passion, face off in a series of increasingly dangerous and gruesome games in order to see who will leave town when all is said and done.
Land owner Logan Andrews (D. W. Moffett) woos the haughty, snobby, and wealthy Margaret Richardson (Pamela Gien) to help finance a development project.
Rock promoter Marty Slash (Lee Arenberg) plans to run off with all of the donation money that has been raised and accumulated from a series of "Save the Amazon rainforest" charity benefit concerts, but things unexpectedly become complicated when it turns out that his hearing problems were nothing more than his conscience (voiced by Sam Kinison) trying to get through to him.
Jim Korman (Harry Anderson), a cartoonist who works on the Tales from the Crypt comic, is put-upon by his shrewish and abusive wife Mildred (Colleen Camp) to take experimental fertility pills.
Theodore (Mike Simmrin), a 12-year-old orphan, is finally able to leave the orphanage he lives in when he is adopted by a rich, childless couple known as the Colberts (William Frankfather and Grace Zabriskie).
Desperate for work, Barry attempts to receive the lead role in a strange production of Hamlet, but is turned down by director Nelson Haliwell (John Astin), who instead gives the part to his handsome rival, Winton Robbins (Bruce Boxleitner).
Inspired by There's Always Tomorrow's no-nonsense main character, Fuschia Monroe (Anita Morris), Janet begins a steamy affair with Abel while Leon is distracted with his work.
After hearing what he believes to be evidence that his lab partners, Sophie Wagner and Pack Brightman (Sônia Braga and Cleavon Little), have purposely injected him with the virus in a plot to kill him, George vows to use what little time he has left to get revenge on his colleagues.
When she learns that Joyce is also participating in a rigged beauty pageant, Helen attempts to knock her unconscious with sleeping pills to take her place and revive her own career, but accidentally causes her to overdose.
In an attempt to boost his sagging ratings, he decides to do a series of episodes from the home of regular caller Nora (Zelda Rubinstein), a strange woman who wants help for her deeply disturbed daughter, Felicity.
After killing Texas ranger "Tracker" Tom McMurdo (David Morse), Billy Quintaine (Neil Giuntoli), a remorseless gunslinger on the run from the law, wanders into a saloon and proceeds to get his comeuppance when the spirits of all of his past victims come back to haunt him.
When a mudslide blocks off the only road out, the hotel manager, Antoine (Dennis Farina), hires Lokai (Timothy Dalton), a werewolf hunter who vows to find and exterminate the beast.
When he ends up arriving at a wrong address, he finds new victims in the form of Ma, Pa, and Winona Brackett (Tim Curry in a triple role), a strange family of rednecks with a fortune buried in their basement.
Believing that his wife, Bridget (Patsy Kensit), is cheating on him, businessman Leo Burns (Héctor Elizondo) hires G. G. Devoe (Sam Waterston), a sleazy and dubious detective, to spy on her.
Nerdy bookworm Stella Bishop (Nina Siemaszko) is tricked by Reggie Skulnick (Anthony Michael Hall), a charismatic jock, into giving him the answers for their upcoming Egyptology test.
In exchange for Finley giving him the answers to the test himself, so he can pass the course and keep his football scholarship, Reggie brings Stella to Finely's home and tricks her into becoming a virgin sacrifice for Ramseth, a long preserved mummy in search of his lover.
"Norma" (Brooke Shields), a criminal hitchhiker stranded on the side of the road in a thunderstorm, catches a ride with Roger (Perry King), a seemingly timid rich man who invites her to stay in his cabin while the storm clears up.
Johnny Canaparo (John Stamos) is a gigolo involved with "Ruthless" Ruth Sanderson (Eileen Brennan), a wealthy and powerful middle-aged woman with heavy connections to the Mafia.
Martin Zeller (Terry O'Quinn), a newly appointed and highly moralistic fire marshal, approaches Puck (Esai Morales), the sleazy owner of The Naked Experience, a strip club where his daughter Hiley (Kimberly Williams-Paisley) was once employed.
Happy housewife Janet McKay (Shelley Hack) finds her day disrupted by Simone, William, and Todd, (Chelsea Field, Jonathan Banks, and Corey Feldman) a trio of CIA operatives who break into her home.
The agents explain that they are searching for her husband (Marshall Teague), whom they believe is Ronald Wald (voiced by an uncredited Cam Clarke), a former assassin gone AWOL, in an effort to kill him.
Gary (Miguel Ferrer) is an abrasive, hot-tempered shock jock who works in a small radio station inherited by his hateful sister Rita (Wendie Malick).
Colonel Parker (Michael Ironside) and Sergeant Burrows (Bruce Payne) are a pair of veterans of Operation Desert Storm who have traveled to Alaska to do some illegal grizzly bear poaching.
The soldiers meet local game warden and fellow veteran Jeri Drumbeater (Vivian Wu), who takes them to an abandoned weather station supposedly used as a hibernation site for bears.
The stipulation mentions that his two sons, the womanizing Justin (Greg Wise) and the greedy Evelyn (James Saxon) must locate their long-lost brother, Frank, within a certain amount of time, or else risk having their inheritance be given away to charity.
In Victorian England, Reverend Johnathan (Anthony Andrews), a corrupt and adulterous priest, discovers that he is the long-lost father of twin daughters: the beautiful and gentle Angelica and the angry and deformed Leah (Anna Friel in a double role).
With the ghosts of his dead brothers helping him escape, Dudley plans to take revenge on the Big Bad Wolf by using a laboratory once owned by a mad scientist to create a zombie pig (also voiced by Brad Garrett).