The series premiered on Disney XD on April 1, 2012, airing alongside the second season of The Avengers: Earth's Mightiest Heroes, as part of the Marvel Universe block.
Spider-Man is frustrated by this seemingly boring assignment, but he begins to suspect criminal activity within Damage Control when he notices their CEO Mac Porter acting suspiciously.
Part 1: Loki joins forces with Doctor Octopus to destroy the Avengers (consisting of Captain America, Thor, Hulk, Iron Man, Hawkeye, Black Widow, Falcon and Spider-Man).
Part 1: Spider-Man learns that the Green Goblin is planning to travel across the Multiverse using the Siege Perilous to collect the DNA of other Spider-Men.
Then Spider-Man heads to a cartoonish world inhabited by anthropomorphic animals where he helps Peter Porker find the will to be Spider-Ham again.
Part 3: As Spider-Man continues chasing Green Goblin across the Multiverse, he lands in a medieval-based world where he helps Spyder-Knight take down the Alchemist (the medieval version of Doctor Octopus) and his Kraken creation to save York.
Jessie and Spider-Man work to save Halloween and the world from the evil plans of le Fay's and henchman Jack O'Lantern.
Part 1: Upon finding the people of New York disappearing and a force field around the city, Spider-Man is attacked by Abomination, Beetle, and Executioner until he is saved by a familiar drone.
Spider-Man discovers that he has been chosen to be the chief game piece of the Collector against Grandmaster who seeks to submit the Earth and once again humiliate his brother.
Part 3: For the fourth game, Spider-Man teams up with Iron Spider, Agent Venom, and Thor against Terrax, Attuma, and Annihilus in a fight within the subway.
Part 1: After defeating Shriek, Spider-Man joins Flash Thompson, Amadeus Cho, Miles Morales, and Ben Reilly for Aunt May's birthday party.
Things get worse when Doctor Octopus completes his Sinister Six upon assembling Kraven the Hunter, Rhino, Hydro-Man, Electro, and Ultimate Green Goblin where they attack the Triskelion.
Part 2: Spider-Man works with Captain America to fight a Carnage-possessed Hulk with help of Iron Fist, Agent Venom, Cloak and Dagger.
Upon being brought to K'un-L'un by Iron Fist, Spider-Man and Kid Arachnid meet with Nick Fury, Doctor Strange, and Madame Web who states that the shattering of the Siege Perilous scattered its fragments to many dimensions and if they are not collected in time, the various universes will collide and be destroyed.
Then Spider-Man and Kid Arachnid arrive in a Wild West dimension where they meet the spider-themed cowboy Webslinger who lost his Uncle Ben when Doc Ock Holliday took over the town.
Spider-Man finds the Siege Perilous fragment in the new machine gun that was provided by Hammerhead's minion Martin Li.
Meanwhile, Mary Jane rounds up Agent Venom, Iron Spider and Kid Arachnid to meet up with Spider-Man to show her transformation as Spider-Woman.
After rounding up Kraven the Hunter, the Rhino, the Scorpion and the Vulture as well as turning Crossbones into a Lizard, Doctor Octopus allows himself to be incarcerated in the Triskelion's security brig by Spider-Man´s team.
The graduation ceremony attended by the Avengers, Doctor Strange, Sandman, Nick Fury, Power Man's parents, Patrioteer, and Ant-Man.