The official title is Ambassador of the Islamic Republic of Pakistan to the United States of America.

From the onset, Pakistan adopted a pro-American policy, with relations taking an upturn in 1954 when Pakistan signed several defense pacts with the United States – first the SEATO and then CENTO in 1955.

Their relations were soured because of the subsequent Indo-Pakistani Wars of 1965 and 1971, but were rejuvenated due to the 1979 Soviet invasion of Afghanistan and the ensuing covert war of 1980–88.

Pakistan's secret nuclear programme led the US to impose sanctions on Pakistan, thus deteriorating Pakistani-American relations, but the War on Terrorism again placed Pakistan in the good books of America, improving the two countries' bilateral relations once more.

Some former ambassadors later rose to command positions in the Pakistani government, with one of them, Muhammad Ali Bogra, becoming the Prime Minister of Pakistan.