His awards in music are credited to him and fellow rock band members of Thirty Seconds to Mars.

For his performance in Mr. Nobody (2009), Leto was listed as the runner-up for the Volpi Cup for Best Actor at the Venice Film Festival.

The film was released in November 2013, receiving acclaim from reviewers and roused nominations for major awards.

Leto played serial killer Albert Sparma in John Lee Hancock's film The Little Things (2021), which earned him nominations for a Golden Globe Award and Screen Actors Guild Award—both for Best Supporting Actor.

The same year, Leto portrays fashion designer and business magnate Paolo Gucci in Ridley Scott's biographical crime drama film House of Gucci, for which he was nominated for a Satellite Award, Critics' Choice Movie Award and Screen Actors Guild Award.