[4][5] The following year, Chastain played the leading role of a CIA agent in Kathryn Bigelow's thriller Zero Dark Thirty, which won her the Golden Globe Award for Best Actress – Motion Picture Drama and the Critics' Choice Movie Award for Best Actress.

[5][6] The part of an unrelenting wife in the crime film A Most Violent Year (2014) garnered Chastain the National Board of Review Award for Best Supporting Actress, and another Golden Globe nomination.

[7][8] For playing an astrophysicist in Christopher Nolan's science fiction film Interstellar (2014), and a mysterious woman in Guillermo del Toro's gothic horror film Crimson Peak (2015),[9][10] she received nominations for the Saturn Award for Best Supporting Actress, winning the award for the latter.

[11][12] Also in 2015, she received a nomination for the Saturn Award for Best Actress for her role as an astronaut in the science fiction film The Martian.

[10][13] Further Golden Globe nominations came for her portrayals of strong-willed titular characters in the dramas Miss Sloane (2016) and Molly's Game (2017), and an unhappily married woman in the miniseries Scenes from a Marriage (2021).