This is a list of diseases known (or declared) to have been eliminated from the United States, either permanently or at one time.
("Elimination" is the preferred term for "regional eradication" of a disease; the term "eradication" is reserved for the reduction of an infectious disease's global prevalence to zero.)
Although no fixed rule always applies, many infectious diseases (e.g., measles) are considered eliminated when no cases have been reported to public health authorities for at least 12 months.
Various public health projects are going on, with a goal of eliminating diseases from the country.
The stated goal of "eradication" of hookworm from the southeast US (1915–1920) was not achieved, although the hookworm-infection rate of that region did drop by more than half.