This page lists polysubstance combinations that are entheogenic, recreational, or off-label indicated use of pharmaceuticals.
For example, the over-the-counter motion sickness combination drug dimenhydrinate (8-chlorotheophylline/diphenhydramine) is occasionally used in higher doses as a deliriant.
The prescription medicine Adderall (dextroamphetamine sulfate/amphetamine sulfate/dextroamphetamine saccharate/amphetamine aspartate monohydrate) is also frequently used recreationally.
The idea is to have be able to experience an enhanced "Candyflipping" with a smoother comedown.
The whole experience is long-lasting and can be too intense as all of these molecules synergize and potentiate each other.