It was founded by leaders of the Presbyterian Church, an affiliation it still loosely maintains, and was formally chartered by the Kentucky General Assembly on January 21, 1819.
[5] The close relationship with the church is evident in Centre's history, as Spragens, the school's seventeenth president, was the first who was not a member of the clergy; even then, he was a Presbyterian elder from age 29.
[5] Fourteen of the school's first sixteen presidents were Presbyterian ministers (excepting only Ormond Beatty and Charles J. Turck),[6][7] though none since Spragens have been.
[19][20] Originally built in 1853, the Italianate-style home was first owned by William Moore, a Danville farmer, and later by George Welsh, a merchant and member of Centre's board of trustees.
[19] When the college purchased the house using funds from a donation given by Henry Nelson Craik, an 1890 Centre graduate, the building was renamed for him.