[3] Most of the original major north–south roads run fully through the city and continue into Mississauga and Caledon, with a few exceptions, mainly in the east end, where three either spur off (or formerly did) from Peel Road 50 (formerly Highway 50) which runs slightly offset from the grid and forms the eastern boundary of the city, or are truncated at the Claireville Conservation Area.

Steeles Avenue is the southernmost arterial in Brampton and runs across the entire city, and is designated as Peel Road 15.

Historically, it was also the southern boundary of the Town of Brampton and the Townships of Chinguacousy and Toronto Gore, and the northern boundary of Toronto Township (later the Town of Mississauga between 1968 and 1974) until the municipal restructuring of 1974 brought it fully within Brampton when the new city limits were set to the south at the-then future Highway 407 corridor and the Canadian National Halton Subdivision.

[12] It was slated be widened to six lanes between North Park Drive and McLaughlin Road in 2020,[14] but the project was shelved after the David Suzuki Foundation, a prominent Canadian environmental group, lobbied for its cancellation, although construction of replacement noise walls and tree-clearing for the road widening were already completed.

As of March 2024, two bridges to cross the river valley are under construction to join the two sections, after several years of delays due to opposition by environmentalists, who successfully stopped an earlier plan to bridge Williams Parkway (which most of Cottrelle east of the river was originally intended to be an extension of) further south.

[16][17] Bovaird Drive runs from the western city limits (at the location where Winston Churchill Boulevard diverts west of the boundary near Norval), where it continues from Highway 7 (Guelph Street) coming from Georgetown (an unincorporated town within Halton Hills), east to Airport Road, where it continues as Castlemore Road.

[12] Before the downloading the road only bore the name east of Main and Hurontario Streets (with the portion to the west simply being Highway 7), and thus was not divided into east–west sections.

Mayfield Road is designated as Peel Road 14 (and historically the 17th Sideroad, a moniker it still carries to the west in Halton Region) and marks the northern boundary of Brampton across the entire city with the Town of Caledon, except for the area around Hurontario Street, where it shifts north to include the entirety of Snelgrove (originally named Edmonton), which straddles Mayfield, within Brampton.

[38] The bypassed section breaks at Williams Parkway (by curving at 90° to become short frontage streets along it) and ends at James Potter Road.

James Potter Road is a modern-built arterial bypass of Creditview Road between Steeles Avenue and Bovaird Drive, and is located entirely east of the Credit River and is a sinuous street that closely parallels a hydro corridor, crossing it several times.

A short section of the road north of Queen Street formed the boundary between the Town of Brampton and the namesake former Chinguacousy Township between 1960 and the 1974 amalgamation.

[4] McLaughlin Road is the westernmost street in the city with designated north and south sections divided by Queen Street between Steeles Avenue and Bovaird Drive McLaughlin generally runs near Fletcher's Creek, with the creek running directly alongside it for most of the section north of Bovaird.

[4] Hurontario (and Main) Street was formerly Highway 10, and is a historic route running north from Port Credit in present-day Mississauga, through Brampton, and terminating in Collingwood.

Its name comes from the two lakes it runs between; Huron and Ontario, and today is subsumed by Main Street between Steeles Avenue and Bovaird Drive.

Uniquely, Hurontario does not leave the city when crossing Mayfield Road but continues a short distance north of it to include Snelgrove, north of which it has ramps connecting to Highway 410, which terminates there as it transitions onto northbound Highway 10 (its present southern terminus) to Orangeville.

[12] The aforementioned Hurontario LRT line was originally proposed to continue up Main to the Brampton GO station, but this section was cancelled after opposition to building it through the downtown area.

[41] Kennedy Road is named after Thomas Laird Kennedy, a former local MPP and the 15th Premier of Ontario, and is designated as Peel Road 16 between Steeles Avenue and Bovaird Drive (with the portions to the north and south being maintained by the city), with the Regionally-maintained section mostly corresponding with the street's busiest and most commercialized stretch.

The CAA Centre arena is located on Kennedy near the southern city limit by Highway 407, as is the back end of the storage and maintenance facility for the under-construction Hurontario LRT.

It has its own unique address numbering anomaly with a numbering sequence distinct from both the main grid and north–south systems for the section between Steeles Avenue and Queen Street Torbram Road's name is a portmanteau of Toronto (likely referring to the former Toronto Township) and Bramalea or Brampton.

It is a very long and busy road beginning at Toronto Pearson International Airport in Mississauga, passing through Brampton, and extending north beyond Peel Region to the boundary of Dufferin and Simcoe counties, where it ends (officially) south of Stayner; a distance of 80 km (50 mi).

Humberwest Parkway runs from Queen Street, opposite the southern leg of Goreway Drive, diagonally northwest to north of Bovaird Drive where it turns west to become Sandalwood Parkway after crossing Airport Road It is named after the west branch of the Humber River which it runs parallel to Goreway Drive is the easternmost road in Brampton to continue into both Mississauga and Caledon, though it changes name to Innis Lake Road in Caledon.

A short section just north of Queen Street is subsumed today by the newer Humberwest Parkway, and a right turn is needed to continue northbound.

However, just north of the 427, it curves eastwards to cross into Toronto, where it continues as one of that city's major east–west streets and eventually reaches Pickering.

It was originally the 9th Concession[1] and ran south through the present conservation area (where the historic bowstring bridge that carried it across the west branch of the Humber River remains in use for a trail), and continued south via Gorewood Drive to Steeles Avenue and beyond along the present course of Finch Avenue.

Ebenezer Road begins as a stub west of McVean Drive just north of Queen Street and ends at Highway 50.

North Park Drive runs north and west of Williams Parkway as a continuation of Howden Boulevard, and runs east to Humberwest Parkway, where it continues as the western section of Cottrelle Boulevard west of the Humber River.