One might consider the listed names unusual due to their containing pop culture references or puns.
In the early days of genomics, genes were often given creative names upon discovery.
[1] Unusual names have caused issues for scientists explaining genetic diseases to lay-people, such as when an individual is affected by a gene with an offensive or insensitive name.
[14] This has particularly been noted in patients with a defect in the sonic hedgehog gene pathway and the disease formerly named CATCH22 for "cardiac anomaly, T-cell deficit, clefting and hypocalcaemia for chromosome 22q11.2 microdeletions".
[17] In 2005, Pokémon threatened to sue the discoverer of POKEMON because the name was attracting attention when its link to the development of cancer was published.