Lithogenes is a genus of South American catfish of the family Loricariidae.

[1] Relative to an undescribed species of Lithogeneinae, L. valencia has sister group relationship to L.

However, unlike most loricariids, species of the genus Lithogenes possess armor plating only on the latter half of the body.

[2][1] L. villosus originates from the Essequibo River drainage of the Guiana Shield.

[4] An undescribed species of Lithogenes is known from the Orinoco basin of the Guiana Shield.