Little Britain is an unincorporated community and census-designated place (CDP) in Little Britain Township, Lancaster County, Pennsylvania, United States.

Pennsylvania Route 272 (Nottingham Road) passes through the center of the community, leading northwest 23 miles (37 km) to Lancaster, the county seat, and southeast 6 miles (10 km) to Nottingham in Chester County.

According to the U.S. Census Bureau, the Little Britain CDP has a total area of 1.5 square miles (3.8 km2), of which 1.7 acres (6,889 m2), or 0.18%, are water.

[4] The community drains west to Little Conowingo Creek, a tributary of Conowingo Creek, and south via Reynolds Run to Octoraro Creek.

Conowingo and Octoraro creeks are both southwest-flowing tributaries of the Susquehanna River, joining the river in Maryland.