Little Collins Street runs roughly from east to west and it bisects the CBD (known as the Hoddle Grid) along its long axis.

The block between Queen and William Streets has a large number of weekday cafes.

The section between Exhibition Street and Elizabeth Street has many Australian fashion boutiques, primarily focusing on men's fashion, such as Joe Black the Tailor, Sarti Tailor, Chiodo, Scanlan & Theodore, Calibre, Saba, Roy Christou, Déclic, Satch and Assin.

International designers Kenzo,[2] Maje, Sandro Paris and Escada[3] have flagship stores on Little Collins Street.

Also located within this precinct are established and well known cafes and restaurants such as Il Baccaro, and the new store allmerch, a division of Bentick and Murphy inc. Australian Roads portal