[1] Many other Little Golden Books have become bestsellers,[1] including Tootle, Scuffy the Tugboat, The Little Red Hen, and Doctor Dan the Bandage Man.

Several of its illustrators later became influential within the children's book industry, including Corinne Malvern, Tibor Gergely, Gustaf Tenggren, Feodor Rojankovsky, Richard Scarry, Eloise Wilkin, and Garth Williams.

Some Little Golden Books and related products have featured popular characters from other media, such as Nickelodeon, Cartoon Network, Disney, Looney Tunes, The Muppets, Sesame Street, Woody Woodpecker, Super Mario, Sonic the Hedgehog, Barbie, Power Rangers, Star Trek, Star Wars, Doctor Who, Thomas the Tank Engine, and others.

The line has also published occasional biographies; examples include The Beatles, Bee Gees, Taylor Swift, Betty White, Dolly Parton and Ruth Bader Ginsburg.

Georges Duplaix, head of Artists and Writers Guild Inc. (a division of Western Publishing), came up with an idea for a new imprint as he was developing books for children.

By increasing the print run to 50,000 copies per title instead of 25,000, they calculated that the books could be sold affordably at 25 cents each (equivalent to approximately $5 today).

The first 12 titles were printed in September 1942 and released to stores in October:[4][5] Three editions totaling 1.5 million books sold out within five months of publication in 1942.

Works coming from this institution became the new basis for the Little Golden Book series, with characters and situations often inspired by the very locale of the Bank School.

As historian Leonard S. Marcus writes: Mitchell had been in discussions with Georges Duplaix and Lucille Ogle as early as 1943 about the possibility of a special series of Little Golden Books written by members of Bank Street Writer’s Laboratory.

In the year 2000, Encore Software produced a series of "Little Golden Books" titles for CD ROM, including The Poky Little Puppy, Mother Goose, Jack and the Beanstalk, The Velveteen Rabbit, Tootle, and The Saggy Baggy Elephant.

This release opened the door for further Little Golden Books that drew upon PG-13 rated licensed film properties; some adaptations in this criterion include the 2016 reboot of Ghostbusters, characters and storylines from the Marvel Cinematic Universe, and Jurassic Park.