She made six complete voyages from Liverpool in the Atlantic triangular slave trade in enslaved people.

On her seventh voyage a French privateer captured her, but a British letter of marque recaptured her.

[3] 1st voyage transporting enslaved people (1784–1785): Captain Robert Ward sailed from Liverpool on 15 June 1784, bound for the Windward Coast.

[4] When Little Joe arrived in Leverpool she reported that she had taken up the crew of the French vessel Providence, which had foundered in the Atlantic Ocean while on a voyage from Charleston to London.

[5] 2nd voyage transporting enslaved people (1785–1786): Captain Ward sailed from Liverpool on 19 August 1785, bound for the Windward Coast.

[6] 3rd voyage transporting enslaved people (1786–1787): Captain Ward sailed from Liverpool on 16 October 1786, bound for the Windward Coast.

[7] 4th voyage transporting enslaved people (1787–1789): Captain Alexander Grierson sailed from Liverpool on 2 December 1787.

5th voyage transporting enslaved people (1789–1791): Captain Richard Jones sailed from Liverpool on 31 December 1789.

[9] 6th voyage transporting enslaved people (1791–1792): Captain Thomas Bridge sailed from Liverpool on 8 April 1791.

[10] 7th voyage transporting enslaved people (1791–1792): Captain Owen Jones sailed for the Windward Coast on 1 August 1792.