In 2001 – when the Little League World Series expanded to sixteen teams – Mexico and the Caribbean were given their own regions.

The region is open to all countries on the Latin American mainland, but is typically contested by the teams from Panama and Venezuela.

Two of the three will send champions to the LLWS each year, while the third will compete in its normal region; the automatic berths will rotate annually.

This scheme is part of a planned expansion of the LLWS from 16 to 20 teams that was originally scheduled to occur for 2021, but was delayed to 2022 due to COVID-19.

As of the 2024 Little League World Series Italics indicates team no longer competes in Latin America Region.