Little Muncy Creek is the major tributary of Muncy Creek in Lycoming and Sullivan Counties, Pennsylvania, United States.
Via Muncy Creek and the West Branch Susquehanna River, it is part of the Susquehanna River drainage basin and waters from it flow ultimately into the Chesapeake Bay.
Little Muncy Creek has its source in Davidson Township in Sullivan County, then flows south in Jordan Township in Lycoming County.
It then flows west into Franklin Township and the village of Lairdsville, running parallel to Pennsylvania Route 118 here.
Further west it enters Moreland Township and passes the village of Opp, before entering Muncy Creek Township, where it flows into Muncy Creek just west of the village of Clarkstown.