Little River is a census-designated place (CDP) in Horry County, South Carolina, United States.

The Little River inlet has long been a breakpoint for tropical cyclone warnings.

The area is mainly made up of housing developments, old scrub pine forests, marshes and swamps and is bordered by the Waccamaw River and the Atlantic Intracoastal waterway.

As of the 2020 United States census, there were 11,711 people, 4,885 households, and 2,633 families residing in the CDP.

In 1996, local churches began protesting legalized gambling in what had become Little Reno, and the state outlawed the games in 2000.

[9] Little River common natural wildlife includes bobcats, lizards (geckos and anoles), amphibians (flatwoods salamander and Carolina gopher frog), non-lizard reptiles (water snakes, yellow-bellied turtles and alligators), wading birds and mammals (black bear and bobcat).