Little Sioux is a city in Harrison County, Iowa, United States.

[4] According to the United States Census Bureau, the city has a total area of 0.37 square miles (0.96 km2), all of it land.

There were 97 housing units at an average density of 270.2 per square mile (104.3/km2).

Hispanic or Latino persons of any race comprised 7.2% of the population.

There were 108 housing units at an average density of 291.9 per square mile (112.7/km2).

33.3% of all households were made up of individuals, and 14.1% had someone living alone who was 65 years of age or older.

There were 111 housing units at an average density of 317.2 per square mile (122.5/km2).

29.2% of all households were made up of individuals, and 16.7% had someone living alone who was 65 years of age or older.

About 13.4% of families and 17.8% of the population were below the poverty line, including 28.0% of those under the age of eighteen and 21.2% of those 65 or over.