Temporarily abandoning her studies, Colleen arrives at her childhood home in Asheville, North Carolina, where she finds her old room exactly how she left it – painted black and covered in goth and heavy metal posters.

The site's critical consensus reads, "Little Sister subverts indie drama expectations with a refreshingly off-kilter look at family dynamics that makes its points through solid characterizations and earnest effort.

Club gave the film a B, saying it was, "a slight, sweetly cynical indie dramedy about family and belonging and the ways we cope with life's disappointments.

"[8] Sheri Linden of The Hollywood Reporter called the film, "Winningly wry and understated," and argued, "Flirting with sitcommy high jinks, Clark instead gives us a bittersweet cocktail of soul-weary defeat and unassuming vigor.

"[9] Peter Travers of Rolling Stone gave the film three out of four stars, stating, "In Little Sister, a skillful blend of humor and heartbreak (minus sappy sentiment), Clark takes us to places and head spaces we don’t see coming."

Travers further added, "Clark takes the story he concocted with producer Melodie Sisk down dark alleys, but Little Sister is never cynical or inhumane...He's made a transfixing film about a family that looks touchingly and unnervingly like yours and mine.