"Little Sister" is the first single released by the rock group Queens of the Stone Age from their fourth album Lullabies to Paralyze.

"[1] When this song was performed on Saturday Night Live on May 14, 2005, actor/comedian Will Ferrell, who hosted the show, came onstage and played the cowbell as fictional Blue Öyster Cult member Gene Frenkle.

This was a reprise of a role that Ferrell played in a famous 2000 sketch in which actor Christopher Walken demands, "More cowbell!"

It has also been featured in the video games Midnight Club 3: DUB Edition, Colin McRae: Dirt 2, and Project Gotham Racing 3.

[2][3] The music video features the band playing in a dark room, with Josh Homme sporting a longer hair style, and girls dancing in the back behind a silhouette screen.