It rises in northern Carroll County, Georgia near the city of Villa Rica and flows southwest into Alabama, joining the Tallapoosa River in Randolph County near the head of R.L.

In May 2012, Aimee Copeland, a 24-year-old graduate student fell from a zip-line into the Little Tallapoosa River.

She suffered a deep cut in her leg and contracted necrotizing fasciitis, a flesh-eating bacterial disease.

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