[5] It is located in a significant cotton-growing region, northwest of Lubbock on the Llano Estacado just south of the Texas Panhandle.

[8] At that time, the ranch covered 312,175 acres (126,333 ha) in Lamb, Hockley, Bailey, and Cochran Counties.

[10] The most westerly piece of debris (a thermal protection system tile) from the 2003 Space Shuttle Columbia disaster was found in a field in Littlefield.

[11][12]: 1.12 According to the United States Census Bureau, the city has a total area of 6.3 square miles (16.4 km2), all land.

American Cotton Growers announced the closure of their Littlefield denim mill[18] on Friday Nov 07, 2014.

[19] The city is headquarters to Lowe's Market,[20] a grocery store chain in the American Southwest.

[25] Police investigation determined that the train was travelling eastbound[24] at 58 mph when it struck the rear half of the northbound bus, causing injuries or death to all 23 students in the bus and injuring the driver, 68-year-old Artis Ray Johnson.

[26] Artis Ray Johnson, the bus driver, was cited by Littlefield police the next day for failure to possess a chauffeur's license, which at the time had the penalty of a $200 fine.

DPS records indicated that Johnson obtained a commercial driving license on June 8, 1959, after four failed attempts.

Despite lacking a proper license, Johnson was hired by Claude Oliver, foreman of Littlefield's school buses.

[29] Teachers reported leading their students in prayer and some discussion, but for the most part, contemporary reports reflected a quiet response from elementary-school students, even as the wrecked bus was temporarily moved into a field within sight of the school.

The first was held at the Littlefield Junior High School auditorium in the morning before classes started, and was for junior-high and high-school students.

[33] As of the 2020 United States census, 5,943 people, 2,134 households, and 1,401 families were residing in the city.

As of the 2000 United States Census,[37] 6,507 people, 2,390 households, and 1,699 families resided in the city.

Lubbock International Airport is served by: Littlefield sits at the crossroads of US Hwy, 84 which runs from Midway, Georgia, to Pagosa Springs, Colorado, and US Highway 385, which runs from Deadwood, South Dakota, to Big Bend National Park in Texas.