Littrow is a lunar impact crater that is located in the northeastern part of the Moon's near side, on the east edge of Mare Serenitatis.

The crater is named after Bohemian astronomer Joseph Johann von Littrow (1781–1840).

The interior has been flooded with lava in the past, leaving a relatively smooth, featureless surface with no central rise.

Part of Rimae Littrow (northwest of the crater Clerke) was considered for a landing site of an early Apollo mission, primarily because the mare materials in the area are anomalously dark, and also because there are abundant wrinkle ridges in the area.

By convention these features are identified on lunar maps by placing the letter on the side of the crater midpoint that is closest to Littrow.