He is best known for serving as the governor of Jing Province (covering present-day Hubei and Hunan) from 192 until his death in 208.

[6] Liu Biao gained control of Jing Province (covering present-day Hubei and Hunan) in 190 CE, when Dong Zhuo appointed him to the position after the death of its previous governor (or inspector), Wang Rui.

Liu Biao later started a war against the warlord Yuan Shu and his minor vassal, Sun Jian.

During the Battle of Xiangyang, Sun Jian was put in command of an army on Yuan Shu's orders to assault Liu Biao in Jing Province.

Huang Zu was outmaneuvered by Sun Jian, but the latter was hit by an arrow and killed, effectively ending the battle in favour of Liu Biao's forces.

To make matters worse, Sun Quan's army had defeated and killed Huang Zu at the Battle of Jiangxia and ultimately destroyed Liu Biao's defences to the east.

Around mid-208, Liu Qi found an excuse to leave Xiangyang and serve as the Administrator of Jiangxia Commandery.

Liu Pan participated in the battles against rival warlord Sun Ce under the command of Huang Zu, the Administrator of Jiangxia Commandery.

Liu Hu also participated in the Battle of Shaxian against Sun Ce under Huang Zu's leadership.

Liu Biao is featured as one of the available warlords that the player can choose from in Creative Assembly's game Total War: Three Kingdoms.