Liu Chi-chun (Chinese: 劉期純; pinyin: Liú Qíchún; Wade–Giles: Liu2 Ch`i2-ch`un2; 1908–1999) was the First Lady of the Republic of China (Taiwan) from 1975 until 1978 as the wife of Yen Chia-kan, former President of the Republic of China.

After that, Yen continued to follow the choice of his parents to marry her in December 1924.

After she became the first lady, she continued to take care of her child, but not to participate on political topics.

After her husband Yen Chia-kan died on December 24, 1993, she died at the same date six years later (in 1999) because of diseases of the lung, liver and kidney at Taipei Chongqing South Road official residence.

Finally, her remains were interred at the Republic Of China Military Cemetery.