The recorded show was performed on December 12, 2009, at the Planet Hollywood Resort and Casino in Las Vegas, Nevada.

This album marks the first official release of acoustic versions of songs from Big Whiskey and the GrooGrux King.

Similar to Live at Radio City, Matthews and Reynolds performed together, with the exception of two songs played solo by Reynolds ("Kundalini Bonfire" and "Kashmir" by Led Zeppelin) and Matthews playing "Some Devil" solo.

For the 2010 holiday season, the Live in Las Vegas video of "Christmas Song" was released through the Dave Matthews Band website.

The piece "Kundalini Bonfire" was nominated for a Grammy Award in the category of Best Rock Instrumental Performance but ultimately lost to the Jeff Beck's "Hammerhead".