Liver and onions is especially common in the regions of Pennsylvania and the Midwest with a strong Germanic culture, for instance in Amish and Mennonite communities.

Beef liver and onions is widely popular in Latin America (Spanish: hígado (de res) encebollado, Portuguese: fígado (bovino) acebolado), where it is often eaten along with tortillas or rice.

In Brazil, the traditional recipe calls for potatoes or other root vegetable, prepared most commonly boiled and puréed or as home fries.

[citation needed] These recipes have also migrated to the large Latin populations in several US cities and are often found on Honduran, Colombian, Cuban and Dominican menus.

In the Powerpuff Girls segment A Very Special Blossom, Professor Utonium claims his favorite dish is liver and onions.

[6] In a later segment titled Lying Around the House, the Powerpuff Girls come to the dining table for lunch, expecting to be given something they enjoy, but instead the Professor serves them liver and onions which they dislike, thus they secretly give the dish to the outside dogs.