[1] The building is on the site of a former inn and a bowling green, which was the birthplace of the businessman and amateur scientist William Roscoe.

The two societies merged as the Liverpool Medical Institution, and commissioned Clark Rampling to design a building to house it.

[7] Inside is a central hall, a lecture theatre, a library, a museum, and meeting rooms, all lit from above by glazed domes.

[8] It organises lectures and social events,[9] runs a library,[10] and hosts meetings of the Liverpool Medical History Society, which was founded in 1984.

[13][14] The Institution also contains an historic library, available to members and researchers, which includes an archive of rare medical books and manuscripts from the 16th century.