The series stars a group of fictional androids who are members of a covert black ops program code named Project Livewire.

Since Stem Cell is straight "out of the box", she still has her default human emotional responses in place and has difficulty adapting to the experiences.

After escaping the site of their battle in Issue 1, the team uses a plasma grenade to destroy Homebrew's remains, buries them, and then proceeds to their next two missions.

To succeed in her mission she has to steal an experimental Sentinel antimatter power core that is being transported aboard a civilian cargo plane.

The team infiltrates a night club that is the evening hang-out of a research scientist who is a known employee for one of their targeted black ops.

Using the codes, Cornfed sabotages the black op's computers and in the process uncovers information that indicates a location where they could gain access to the highest priority target on their list.

The team stows aboard a tanker truck containing a shipment of inert nanofluid that is being delivered to the White Whale by AIM.

At the arrival point, a huge black robot appears and takes the entire tanker up to the White Whale's headquarters.

The battle ends when Stem Cell uses plans stolen from Thermogentech's files to create an upgraded version of the Pyronanos.

Stem Cell designs these Pyronanos to run even hotter than the originals; she plans for the resulting explosion to destroy the Helicarrier.

Lost in the resulting fight between the Pyronanos and the White Whale, Stem Cell recovers the remains of Cornfed and Social Butterfly.

After reaching the ground, Stem Cell recovers the fused remains of Gothic Lolita and sets out for Project Livewire's headquarters with what is left of her teammates.

A "digest format" trade paperback titled Livewires: Clockwork Thugs, Yo was published on October 10 of the same year.