The episode features guest performances by Max Burkholder, Gary Cole, Rob Corddry, Judy Greer, Jonathan Morgan Heit, Kevin Michael Richardson, Sage Ryan, Tara Strong, Nicole Sullivan, and Josh Robert Thompson along with several recurring voice actors for the series.
While there, Stewie meets a boy named Scotty Jennings and his parents Ben and Hope, whom Lois and Peter befriend.
When Scotty's parents Ben and Hope arrive, they confess that they already knew their son had cancer, but do not use modern hospital treatment due to their religious beliefs as Christian Scientists, stating that they use their faith as a medicine.
Lois and Peter's plans are thrown into turmoil when news spreads of their kidnapping and a huge mob with Tricia and her cameraman (along with her super protective painter boyfriend, Tyrone) and the police with Joe stop them at the hospital.
Eventually, Ben and Hope agree and allow their son to go to the hospital to receive his treatments, prompting Peter to exclaim "Hey Everybody, We're All Gonna Get Laid!"
At the end of the show, Peter decides to study Christian Science and proves a theory by imagining himself as Duchess Kate Middleton at the Royal Wedding.
[1] A review by Kate Moon of TV Fanatic was even more overwhelmingly positive, claiming that the show delivered a "genuine message".