LIU opened in January 2012 on a leased campus near the center of Mbale, Uganda, by road it is approximately 250 kilometers (160 mi) northeast of Kampala, the capital and largest city in that country.

The first step in this process was accomplished December 19, 2008 when the NCHE issued to LIU a Letter of Interim Authority.

This allowed LIU to begin buying property, prepare curricula, hire faculty and staff and set up banking and other business tasks.

The building will be a multi-million dollar (Approximatively USD $4 M) The property has acquired its freehold land title at the beginning of the year 2021.

LIU is gender oriented[clarification needed] and works for equal opportunity for both female and male students.

Each student at LIU is issued an electronic tablet or laptop as a medium for accessing textbooks as well as receiving other instructional materials and assignments from lecturers.

Students in the Media Technology program receive hands-on experience in digital video and audio production on up-to-date equipment in the university's own studio.