[2] In early 2018, the adjacent Mangochi Forest Reserve was also brought under African Parks' management, almost doubling the size of the protected area.

[9] Liwonde has a 129-kilometre (80 mi) perimeter, which was unfenced until the nonprofit organization African Parks confirmed plans to construct a fully fenced border in 2015,[10] which has since been completed.

[11] The Mangochi Forest Reserve forms part of a proposed ecoregion, to be called the South East Africa Montane Archipelago (SEAMA).

The project, which reportedly lasted from April to December, was managed by USACOL and CBNRM, both of which are part of the Coordination Union for the Rehabilitation of the Environment.

According to CBNRM's national coordinator, the project encouraged local communities to "participate in the conservation and management of natural resources".

Since 1990, elephants, black rhinoceros, elands, impalas, kudu, sables, warthogs, waterbuck, and zebra have been relocated to or from the park.

The Liwonde Rhino Sanctuaries led to the growth of a number of other species, particularly buffalo, eland, Lichtenstein's hartebeest, roan antelope, zebra, and sable antelope, allowing for animals of those species to be moved to other parks, particularly Kasungu National Park.

The translocation was carried out by African Parks, in conjunction with WWF South Africa, the DNPW, and Ezemvelo KZN Wildlife.

In an effort to boost the park's hyena numbers, six individuals were reintroduced from a private property in Kasungu, bringing the population to about 25.

Biome-restricted bird species in the park include: white-starred robin, brown-headed parrot, brown-breasted barbet, pale batis, Dickinson's kestrel, Lilian's lovebird, Böhm's bee-eater, racket-tailed roller, pale-billed hornbill, Kurrichane thrush, Arnot's chat, white-bellied sunbird, black-eared seedeater, broad-tailed paradise whydah, Meves's starling.

In 2011, Birdlife International and the Good Gifts Catalogue raised funds to survey and monitor the threatened Lilian's lovebird.

[31] Park rangers and local students worked with the Wildlife and Environmental Society of Malawi to research Lilian's lovebirds in 2012.

[15][16] African Parks has made over 100 arrests and installed 120 km of electric fencing in an effort to reduce conflict and poaching.

[8] Other plants in the park include: acacias, miombo, Albizia harveyi, Adansonia digitata, reedbeds along the rivers, evergreen forests fringing tributaries,[8] Acacia xanthophloea (fever tree),[15] Borassus (Palmyra palm), capers, Hyphaene coriacea (lala palm), and Kigelia (sausage trees).

[14] Before the building of a fence, people living near the park argued in support of its construction, saying that the animals were damaging their crops.

The camp features classic safari tents, private verandahs, outdoor bathrooms, and stunning views of the Shire river.

The lodge, established in 1995, is operated by Central Africa Wilderness Safaris,[4][24] a company known for its sustainable practices and willingness to support local communities and conservation efforts.

Lilongwe Wildlife Trust also run a research volunteer placement programme in Liwonde National Park focussing on iconic species such as lion, cheetahs, and hyena.