It is located west of Kasungu, about 175 km north of Lilongwe, extending along the Zambian border.

Kasungu National Park, established in 1970, is the second-largest in Malawi at 2,316 square kilometres (894 sq mi), with an elevation of approximately 1,000 metres (3,300 ft) above sea level on average.

It is located in the Central Region approximately 165 km (103 mi) north of Lilongwe.

The vegetation consists mainly of Miombo woodland with grassy river channels, known locally as Dambos.

Predators in Kasungu National Park include, hyenas, Cape wild dogs and servals.