She is known for roles such as the convicted murderess, Pat Kerrigan, on ITV1's Bad Girls, and Agent Johnson in Torchwood: Children of Earth.

Brice has appeared in episodes of BBC's Hustle and played the role of Medic in the film version of Resident Evil.

She has also starred in her former partner Charlie Brooker's zombie horror Dead Set, and appears as Government assassin Agent Johnson in Torchwood's Children of Earth, aired in July 2009.

In 2013, Brice played a character called Tara - the new love interest for Billy Mitchell (Perry Fenwick) - in the soap opera EastEnders.

In 2014, Brice voiced Licia of Lindeldt & Milibeth in Dark Souls II, and later portrayed Gainsborough in the Black Mirror holiday special titled "White Christmas".