Born into a noble family in rural Guria, then part of the Russian-controlled Georgia, Liza Nakashidze married a peasant, surnamed Bolkvadze, and became involved with the Social Democratic Party in 1904.
She was active in the local revolutionary movement—known as the Gurian Republic—and headed a women's Social Democratic group in Guria during the Russian Revolution of 1905.
After a period of arrest and exile by the Imperial police, she reentered the Georgian politics shortly after the February Revolution topped down the Russian monarchy in 1917.
She became chair of the Gurian Women's Society in March 1917 and elected to the Constituent Assembly of a newly independent Georgia on a Social Democratic Party ticket in 1919.
Eventually, in February 1938, she was hastily tried by the NKVD troika while being in exile in Minusinsk on charges of being in touch with the Georgian political emigres in Europe and of leading a counterrevolutionary organization.