Initially affiliated with the Woman's Union Missionary Society of New York, she began providing services in India and Japan in 1868.
Elizabeth (nickname, "Lizzie")[1] M. Guthrie was born in Bakerstown, Allegheny County, Pennsylvania, 1838,[2][1] a village about 18 miles (29 km) north of Pittsburgh.
[3] Guthrie's attention was soon turned to the subject of missions, and, after due deliberation, she made up her mind to go out as a missionary in the foreign field.
Contrary to expectation, however, the sea voyage proved beneficial; Guthrie's strength began to return; and when she reached Japan, the improvement in her condition was very marked.
At length, having entirely recovered from her illness, and her services being needed in Japan, she entered actively into the mission work, under the direction of the Union Board, and remained there for six years.
[3] During her stay in Japan, the funds of the Union Board were taxed, and she was directed not to receive any more girls into her school, as there were no means available for their support.
The Woman's Union Board presented a way through which they could carry out their purpose, and it was soon reported that the Methodist Protestant Church had made provision for the support of two girls.
When she found she was about to die, Guthrie hurriedly made a will, and left her money and effects, including her library in Japan, to the Woman's Society of the Methodist Protestant Church.