[1] In 1893–1894, Griscom served in the United Kingdom as secretary to Ambassador Thomas Bayard; he was admitted to the bar in 1896,[1] and the following year in 1897 he was deputy district attorney of New York.

[1] While serving a short period as Secretary of Legation and chargé d' affaires at Constantinople, the 28-year-old Griscom made a notable achievement in 1900 by persuading the Sultan to purchase what would become the Ottoman cruiser Mecidiye from the American shipbuilder William Cramp & Sons.

[9] He was a close friend of Col. Theodore Roosevelt Jr.[2] Griscom's primary significance was as an advocate for globalized free trade as a means to promote peaceful development in accordance with his Quaker faith.

In the Middle East he worked for better relations between Muslims and Christians, and he played a major role in the relief effort in Italy after the 1908 Messina earthquake took 50,000 lives.

Leo Amery, M.P., commented that "My old friend Lloyd Griscom gives a delightfully breezy picture as seen through American eyes of Edwardian England, of the diplomatic world, of many countries.

"[11] Following his retirement from public service, he bought and became the publisher of several Long Island newspapers, including the East Norwich Enterprise, the North Hempstead Record, and the Nassau Daily Star.

[14] Griscom died of a stroke on February 8, 1959, at Archbold Memorial Hospital in Thomasville, Georgia while visiting his sister Frances who was a patient there.

[29][30] After his death, his widow, who inherited the bulk of his estate including the Leon county Luna Plantation as well as the Tallahassee Democrat, which she ran from 1958 through 1965.