The building was listed on the National Register of Historic Places in 1978 and designated as a Baltimore City Landmark in 1971.

The Lloyd Street Synagogue was built by the Baltimore Hebrew Congregation, incorporated on January 29, 1830,[3] as Nidche Yisroel.

[4] For the first fifteen years of its existence, services were held in a small room above a local grocery store.

Isaac Leeser of Philadelphia, together with the ministers of the congregation, Abraham Rice and A. Ansell (Anshel).

[7][1] Baltimore architects Robert Cary Long, Jr. and William Reasin designed the building in the fashionable Greek Revival style.