The recording features six number one United States Billboard Hot Latin Songs chart singles by the singer—"Buenos Amigos", "Donde Quiera Que Estés", "Amor Prohibido", "Bidi Bidi Bom Bom", "No Me Queda Más", "Fotos y Recuerdos", and the US Billboard Latin Pop Airplay chart single "I Could Fall in Love".

Lo Mejor de...Selena debuted and peaked at number 102 on the US Billboard 200 chart, her highest-charting album since 1999's All My Hits/Todos Mis Exitos.

The album has been certified by the Recording Industry Association of America (RIAA) double platinum, denoting 120,000 album-equivalent units.

[nb 1] In the fall of 2011, Chilean record producer Humberto Gatica and Capitol Latin senior vice president Sergio Lopes had the idea of turning Selena's songs into duets in popular music genres.

[11] Lo Mejor de...Selena contains six Billboard Hot Latin Songs chart number one singles by the singer—"Buenos Amigos", "Donde Quiera Que Estés", "Amor Prohibido", "Bidi Bidi Bom Bom", "No Me Queda Más", "Fotos y Recuerdos", and "I Could Fall in Love"—the latter of which peaked at number one on the Billboard Latin Pop Airplay chart.

[12] "No Debes Jugar", the lead single from 1993's Live!, and "La Llamada" made the album cut.

[27] Terra Chile also called the album a way to "remember and honor the legacy of [Selena]" and said that her "departure still lives in the hearts of her fans.

"[28] The newspaper called the addition of "Disco Medley" on Lo Mejor de...Selena as having a "new voice on [the] classics" of "I Will Survive", "Funkytown", and "On the Radio".

[37] After the 2016 Billboard Latin Music Awards nominations were announced, Spanish-language channel Telemundo called Selena a "role model for Latinos" and that her "voice continues to echo and touch the hearts of audiences, regardless of gender.