The program is based on numerous impersonation of famous people and popular films and TV shows, prank calls and dirty talk.

According to an Il Sole 24 Ore survey, in 2004 was the most appreciated radio show from an audience between 12 and 29 years of age.

[2] On 17 December 2009, the American actor Benjamin McKenzie and on 6 June 2014 David Hasselhoff, have participated in Lo Zoo di 105 as guest stars.

[3][4] In 2010 Lo Zoo di 105 started airing the longest prank call ever, named Alan in love.

In this prank, Alan Caligiuri (a former host of the show) called several elderly people from all around Italy searching for love and he eventually found one.