Loakes Park became the home of Wycombe Wanderers when their previous ground, Spring Meadow, was sold, thus making it unavailable for football.

An approach was made to Lord Carrington, owner of the estate which included Loakes Park, for permission to play football there.

Only after the Home Secretary had overturned the initial rejection of a proposed ground at the end of Hillbottom Road in the Sands district of High Wycombe, could Wycombe Wanderers begin work on their new ground in 1989, funded largely by the proceeds from the sale of Loakes Park.

The record attendance was 15,850 for an FA Amateur Cup Fourth Round tie on Saturday 25 February 1950, when Wycombe Wanderers beat St Albans City 4–1.

Arguably the most memorable match to be played at Loakes Park was in the FA Cup Third Round on Saturday 4 January 1975.