The show focuses on the lives and experiences of Latinx femmes through discussions on various topics like mental health, art, politics, and gender expression.

[3][1] The two began following each other on Twitter and Instagram before eventually meeting in person at an event hosted by Chingona Fire, a women of color poetry collective.

They launched Locatora Radio in 2016 in part to address the dearth of representation of Latinx, femmes, and assault survivors doing podcasts that intersected with academic analysis.

[1] The aesthetic of the podcast is femme, and their digital marketing materials draw on Mexican film posters from El Siglo de Oro that portrayed women as villains.

"[1] The hosts refer to themselves as Las Mamis of Myth & Bullsh**t.[5] They sometimes interviews guests, such as Afro-Peruvian choreographer Nadia Calmet, and Linda Yvette Chavez and Marvin Lemus, the creators of the Netflix series Gentefied.

[10] They also hosted podcasting workshops at 11 branches of the Los Angeles Public Library for the institution's 2020 LA Made series.