Locust Grove is a city in Henry County, Georgia, United States.

The community was named for a grove of locust trees near the original town site.

A group home sharing the site was previously licensed by the state of Georgia to provide residential care for up to 24 children but has since closed.

Locust Grove has a platform for watching the Norfolk Southern line that runs parallel to State Route 42/US Highway 23.

It is equipped with a scanner radio that allows visitors to the platform to listen in to the local railroad frequency, which broadcasts out of the defect detector in nearby Jenkinsburg.