AFC Wimbledon started the 2020–2021 season sharing the ground while they waited for their new stadium in Merton to be finished.

In 1985, Barry McGuigan defeated Eusebio Pedroza for the World Boxing Association featherweight championship at the stadium.

[5] QPR moved to Loftus Road in 1917, having had their ground at Park Royal commandeered by the army in February 1915.

[6] In 1938, a new covered terrace for 6,000 spectators was constructed by a company called Framed Structures Ltd at the Loftus Road end, taking the overall ground capacity up to 30,000.

It cost £7,000 (with £1,500 donated by the QPR Supporters Club) and was opened by Herbert Morrison, the leading Labour MP and future wartime Home Secretary, at the match against Crystal Palace on 29 October.

In the summer of 1968 the South Africa Road stand was constructed at a cost of £150,000 to replace the old open terracing.

[6] In 1972 a new stand was completed in Ellerslie Road, replacing the tin-roofed grandstand erected in 1919, and first used in the match against Oxford United on 2 December 1972.

During the summer of 1981 an artificial pitch of Omniturf was installed at Loftus Road, the first such surface to be used in British professional football.

[9] The surface was not favoured by everyone, with QPR keeper Peter Hucker describing it as "basically a bit of carpet over two feet of concrete", and stated that as a goalkeeper, he strongly disliked diving onto it saying that "I'd have close to third degree burns because the pitch would totally rip the skin off.

During the time that Loftus Road had the Omniturf pitch installed, QPR reached two cup finals and became Second Division champions, something that critics claimed was caused by the advantage the pitch presented,[9] and QPR's home games in the 1984–85 UEFA Cup were played at Arsenal's Highbury Stadium.

[11] The owning company, also called Loftus Road, of QPR, London Wasps and the stadium itself, went into the red in the late 1990s only a couple of seasons after it was formed in 1996.

[12][13] In 2001, there were concerns that Queens Park Rangers and the stadium would need to be sold separately when the club went into administration.

[14] A supporter's trust was set up to keep the club at Loftus Road, and to fight the suggested move out of the stadium and to Milton Keynes.

[17] A £1 million payment by QPR's long time local rivals Fulham in 2002 helped to alleviate the financial problems in return for a ground sharing agreement while Craven Cottage was developed.

[21] In February 2022 the club announced a fundraising campaign, asking supporters to pay for the planned renaming costs.

Following a number of years of uncertainty about whether the club would expand the capacity of the stadium, or relocate to a new site in the event of a return to the Premier League, chairman Tony Fernandes announced, on 28 November 2011, that the club was investigating the possibility of relocating to a new site in West London in order to build a larger stadium.

The Loft is a two tier stand built in 1981 behind the goal and is traditionally where most members and season ticket holders sit.

A new colour scoreboard is located at this end, installed in Summer 2008, on the advertising boards between the upper and lower tiers.

As of August 2022 The Lower Loft contains 726 rail seats used for safe standing in Blocks ML, NL and PL.

It is also home to the commentary and television camera gantry, and is the only stand whose seat colours are not arranged in blue and white hoops, spelling out "QPR" instead and chants of “captain jack” can be heard echoing around the stadium At the west end of the stadium is the Achilles Security Stand.

[31] It was part of a 7-year ground share deal negotiated by Chris Wright who had just bought Wasps as rugby union became professional.

Wasps agreed to move out, to Wycombe Wanderers' Adams Park ground, at the end of the 2001–02 season to allow Fulham F.C.

[34] The venue has also been used to host boxing in the past, with the most notable bout being between Irishman Barry McGuigan and Panamanian Eusebio Pedroza on 8 June 1985 for the WBA featherweight championship in front of a sold out capacity of 27,000 spectators.

McGuigan knocked the Panamanian down in the 7th round en route to a unanimous decision win: Pedroza was making the nineteenth defense of his title, and Ireland had not had a boxing world champion for 35 years.

The application was rejected as there were already five scheduled matches over the course of thirteen days as it was during the time that QPR were sharing Loftus Road with Fulham.

From South Africa Road to the north, the 228 runs in both directions, terminating at Maida Hill and Central Middlesex Hospital.