[12] Two partially retractable roof structures over the east and west ends of the stadium can be opened to allow sunlight and aid pitch growth.

In 2004, London Mayor Ken Livingstone and Brent Council also announced wider plans for the regeneration of Wembley, taking in the arena and the surrounding areas as well as the stadium, to be implemented over two or three decades.

2004 also saw errors, most notably a fatal accident involving carpenter Patrick O'Sullivan for which construction firm PC Harrington Contractors were fined £150,000 in relation to breaches of health and safety laws.

[29] On 20 March 2006, a steel rafter in the roof of the new development fell by 1+1⁄2 ft (46 cm), forcing 3,000 workers to evacuate the stadium and raising further doubts over the completion date which was already behind schedule.

The twice life-size bronze statue, sculpted by Philip Jackson, depicts England's 1966 World Cup winning captain Bobby Moore, looking down Olympic Way.

[47] The Football Association admitted in April 2009, after the FA Cup semi-finals, that improvements were needed to the Wembley pitch, after criticism of the surface by coaches Alex Ferguson, Arsène Wenger and David Moyes.

In April 2010, the pitch was again criticised following the FA Cup semi-finals, during which the players found it difficult to keep their footing and the surface cut up despite the dry conditions.

"[50] The stadium was then relaid with a Desso GrassMaster semi-artificial pitch, ahead of the 2010 community shield game between Chelsea and Manchester United.

[53] Despite the pitch's condition, UEFA allowed a Champions League leg to be played at Wembley on 6 November 2018 with Tottenham hosting Dutch side PSV Eindhoven.

[41] The primary reason for the sliding roof was to avoid shading the pitch, as grass demands direct sunlight to grow effectively.

[68] On 18 July 2018, a parliamentary select committee was held to discuss the possible sale, with evidence being given by former player, Gary Neville, and Katrina Law of the Football Supporters' Federation.

The new Wembley was a significant part of the plan for the 2012 Summer Olympics in London; the stadium was the site of several games in both the men's and women's football tournaments, with the finals being held there.

[72] The FA offices at Wembley Stadium, with social areas and boardroom, were designed by architects Gebler Tooth – who were also responsible for Team GB House at the London 2012 Olympics.

Ex-England international Guppy is also the first player to win a final at both stadia (with Wycombe Wanderers and Leicester City in the old Wembley, then Stevenage Borough in the new one).

The second FA Cup final held at the new stadium took place on 17 May 2008, with Portsmouth winning the title 1–0 against Cardiff City; Nwankwo Kanu scored the only goal.

On 24 August 2013 their Year 7 Rugby team played RGS High Wycombe in the annual schools curtain-raiser to the Challenge Cup final.

In 2015, a second statue was erected outside of Wembley, depicting Rugby League legends Martin Offiah, Alex Murphy, Eric Ashton, Gus Risman and Billy Boston.

The double header drew 67,575 fans to Wembley, the second highest crowd for an international rugby league game at either the original or the new stadium.

"[115] On 28 October 2007, in front of 81,176 fans, the New York Giants defeated the Miami Dolphins by a score of 13–10 in the first NFL regular season game ever to be played in Europe, and the first outside of North America.

[123] In 2015, another first occurred as the first ever divisional match took place at Wembley between the American Football Conference – Eastern Division's Miami Dolphins and New York Jets.

[127] On 31 May 2014, Wembley Stadium hosted its first boxing event, featuring the rematch between Carl Froch and George Groves for the WBA and IBF super-middleweight titles.

[137] Other acts to have performed at the stadium are The Stone Roses,[138] Adele, Rihanna, Ed Sheeran, The Weeknd, Mötley Crüe, Metallica, U2, The Killers, Linkin Park, Green Day, Foo Fighters, Eminem, Madonna, Taylor Swift, Jeff Lynne's ELO, Beyoncé, Spice Girls, Coldplay, Harry Styles, Oasis, Take That, BTS, One Direction and AC/DC.

The summer's final show saw former Pink Floyd bass guitarist Roger Waters play at the venue on 14 September as part of The Wall Live tour.

The concert was documented and aired on 16 August 2015 on NBC; the one-hour special Ed Sheeran – Live at Wembley Stadium also included behind-the-scenes footage.

It was originally scheduled to conclude on 2 July 2017, however on 30 June Adele announced via social media that she had regretfully cancelled her final two performances upon medical advice due to vocal injuries.

[153] The three-night sellout stand was the highest-grossing engagement of the year, winning the Spice Girls the 2019 Billboard Live Music Award for Top Boxscore.

On 6 August 2022, after two years of postponement because of the COVID-19 pandemic restrictions, Irish pop band Westlife performed for the first time at the stadium with a recorded screenplay at ITV on 20 November 2022.

On 3 September 2022, the Foo Fighters played in a sold out Wembley to pay tribute to their late drummer Taylor Hawkins, with guest appearances from Liam Gallagher, Queen, Brian Johnson, Lars Ulrich, Them Crooked Vultures, Paul McCartney and many others.

[158] The Weeknd brought his After Hours til Dawn tour on 18 August 2023 which broke the record for the most tickets sold with the "traditional concert set-up", having 89,179 people.

To alleviate the impact of vehicular traffic on the local residents and businesses, Brent Council have introduced a number of measures in relation to on street parking and to access restrictions of roads that surround the stadium.