Pain episodes are rarely associated with low-grade fever and dysuria, but urinary tract infection is not present.

The major causes of flank pain and hematuria, such as nephrolithiasis and blood clot, are typically not present.

LPHS is a debilitating disease due to chronic pain and the inability to know how to control the glomerular aspect.

The pain of LPHS can be worsened by acts as simple as riding in the car and undertaking daily activities.

[citation needed] Treatment of loin pain-hematuria syndrome (LPHS) typically consists of pain management.

Occasionally, people with LPHS require hospitalization for intravenous opioid therapy and control of nausea.

Limited evidence suggests that drugs that inhibit angiotensin may reduce the frequency and severity of episodes of loin pain and gross hematuria.

[citation needed] Possible treatment regimens[7] Surgery (autotransplantation) is thought by some to be of benefit in selected individuals[8] and advocated in some centres, but usually considered the last resort.

[10] While exact numbers worldwide are not available, the primary LPHS research clinic located in Ohio has over 200 patients.