Lola was born around 1874 to Ket and Ejih,[n 1] a Selk'nam couple from the Tierra del Fuego island, now jointly owned by the Chilean and Argentine governments.

She had seven children with her first husband, Anik, a haush who was badly wounded in the knee during a battle making part of the Selk'nam genocide, which halted her process of becoming a shaman.

All of her children predeceased her: her only living descendants at the time of her death were a granddaughter adopted by the priest Luis Garibaldi Honte and a great-grandson.

In 1964, American ethnologist Anne Chapman traveled to Tierra del Fuego for the first time to record Selk'nam traditions and songs, including the testimony of Lola Kiepja.

[5] In the winter of 1966, she was transferred against her own will to the Rio Grande Regional Hospital due to a grave sickness, despite her having declared that she would prefer not to leave her hometown anymore.